Climb for Autoimmune Disease Research

Climb Dashboard

A blog article by Ashlie Reker, Ph.D.

Autoimmune diseases result from the inability of one’s immune system to differentiate between cells of the body or “self cells” and foreign cells or “non-self cells”. This can ultimately lead to the body launching an immune response against self-cells that are mistaken as foreign – that is, the body attacks itself.

Currently, 5-8% of the global population is afflicted with one of the 80 known auto-immune disorders, to include Lupus, Psoriasis, and Type 1 Diabetes, and historical evidence suggests these numbers will continue to rise (Fugger, L. et al., 2020; Dinse, G. E. et al., 2020). Genetics, intracellular signaling, lifestyle, environment, and their interactions have been identified as underlying mechanisms for the development of auto-immune disorders.

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Climb for Neuroscience

brain neurons

A blog article by Ashlie Reker, Ph.D.

Fairly recently, the field of neuroscience seemed to be suffering from brain drain  (Sifferlin, Alexandra, 2014; Markram, Henry, 2013). Advances in our understanding of how the central nervous system functions, and the physiological and behavioral manifestations of these functions, and dysfunctions, were slow. As a result, the development of innovative treatments for conditions bearing high burden of disease, such as neuropsychiatric disorders and dementia, were significantly lacking.

New technological innovations allowed for a resurgence in neuroscience research output, so much so that some have dubbed the 2010s as “The Decade of The Brain”.

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Where Climb Fits in the Drug Discovery Process

Where Climb fits in the drug research process

Climb can help your research team streamline in vivo drug discovery.

The drug discovery process is a long and winding road from target discovery to FDA approval and getting the finished product to market. Climb fits smoothly in the middle of this journey in the in vivo research stage and will streamline your lab by:

  • Managing your animal colony with ease
  • Housing your study design, protocols, schedule, and assignments all in one convenient location
  • Managing your samples
  • Searchable, harmonized data

RockStep Solutions is partnered with Dotmatics which allows Climb to integrate smoothly with the rest of their upstream and downstream capabilities. Our API capability also integrates with lab equipment like scales and calipers and will automatically transfer data reducing the risk of human error!

Interested in learning more about how Climb can help your research team? Request a demo today!

Improve Your Lab’s Collaboration

Improve your in vivo research efficiency

Climb can improve collaboration across your entire team, from scientists to vivarium managers and vet techs, by giving everyone involved in the in vivo research process the information they need to get their jobs done correctly and efficiently.

Scientists use Climb to design their studies and provide detailed instructions to lab technicians. Study directors use Climb to manage all aspects of the laboratory workflows and scheduling. At the lab bench, technicians use Climb to guide their work and capture experimental data.

Climb’s native cloud technology allows for secure, on-demand access from anywhere, reducing data silos and improving communication.

RockStep’s in vivo management solution Climb helps labs get more cures to market faster.  Take the video tour or request a demo!

Cage Cards in Climb 2.0

A blog article by Karissa Panzino

About Cage Cards

Data collection and record keeping is critical when it comes to in vivo research management. Amongst other practices, cage cards are an efficient way to capture important information about the animals being worked with and can help minimize errors. They display critical information such as IACUC protocol while also providing at-a-glance details on animals.

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5 Ways Climb Can Improve your in vivo Research Efficiency

A blog article by Ashlie Reker, PhD., and Ben Wyman, M.A.

1. Accurate, Harmonized Data

Collecting and analyzing data is the reason we do science. Whether for the pursuit of pure knowledge or intentionally identifying lead targets for drug discovery, in vivo research is invaluable to these processes. Increased proficiency and accuracy of bioassays and phenotyping output in this space has led to greater quantities and quality of data. “Big data”, for example, requires collaborative efforts by highly trained statisticians to analyze massive data sets to derive meaningful and applicable conclusions.

Climb aggregates and harmonizes data in the secure Azure cloud promoting accurate, and immediate collaboration between all facets of the R&D and drug discovery processes. Intuitive functionality, data locking, and audits allow data to be located and shared as an export or with role-based access to your instance of Climb. Climb makes data management a breeze.

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