A blog article by Ashlie Reker, Ph.D.
Genes are segments of DNA that encode for proteins and molecules. The translation of DNA into mRNA and the subsequent transcription of that mRNA results in those segments becoming the proteins and molecules that allow our bodies to function properly. In consideration with one’s genome is the epigenome (“above the genome”) which regulates the expression of genes from the genome without interacting with DNA.
The expression of genes determines an individual’s phenotype (set of observable characteristics or traits) for example, having blue or brown eyes. Alterations, both naturally occurring and environmental, in the genome, epigenome, or a combination thereof underlie the etiopathology of many diseases. Advances in techniques to study how these alterations contribute to disease are offering tremendous insight into drug discovery and development.
Climb For Genetics Research
Simple Colony Management
Using these features, you can also quickly ascertain which strains require more, or less breeding to maintain the colony or prepare for an upcoming study. Climb tracks animal pedigree for strains bred in-house, giving you a comprehensive history for each animal.
In addition to breeding for genotypes, the “Constructs” facet allows you to record critical metadata for your induced models, including antibody, vector size, and transgene excision. These constructs can also be associated with an animal strain. Similarly, Climb is able to associate genetic editing specifications, for example using CRISP-Cas 9, with animals.
Best of all, there is no limit to the number of animals, strains, genotypes, or constructs that can be recorded in Climb!
Collaborate from Anywhere
Get More out of your Study Data
Efficient Sample Management
Empower your scientists, research associates, and vivarium staff to work collaboratively, efficiently, and quickly in Climb’s cloud platform.
Taken together, Climb 2.0 makes will help you get more therapeutics to market faster!
Want to learn more about Climb 2.0? Take the video tour or request a demo!
