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Climb for Genetics Research

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A blog article by Ashlie Reker, Ph.D.

Genes are segments of DNA that encode for proteins and molecules. The translation of DNA into mRNA and the subsequent transcription of that mRNA results in those segments becoming the proteins and molecules that allow our bodies to function properly. In consideration with one’s genome is the epigenome (“above the genome”) which regulates the expression of genes from the genome without interacting with DNA.

The expression of genes determines an individual’s phenotype (set of observable characteristics or traits) for example, having blue or brown eyes. Alterations, both naturally occurring and environmental, in the genome, epigenome, or a combination thereof underlie the etiopathology of many diseases. Advances in techniques to study how these alterations contribute to disease are offering tremendous insight into drug discovery and development.

Climb For Genetics Research

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Simple Colony Management

It’s easy to assign a genotype to an animal in Climb, just drag and drop! You can also associate several genotypes to a particular animal. Finding animals with the correct gene expression for your experiments is simple with Climb’s search and custom configuration functionality.
Climb genotype capabilities

Using these features, you can also quickly ascertain which strains require more, or less breeding to maintain the colony or prepare for an upcoming study. Climb tracks animal pedigree for strains bred in-house, giving you a comprehensive history for each animal.

In addition to breeding for genotypes, the “Constructs” facet allows you to record critical metadata for your induced models, including antibody, vector size, and transgene excision. These constructs can also be associated with an animal strain. Similarly, Climb is able to associate genetic editing specifications, for example using CRISP-Cas 9, with animals.

Best of all, there is no limit to the number of animals, strains, genotypes, or constructs that can be recorded in Climb!

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Collaborate from Anywhere

Because Climb is a native-cloud application, monitoring the animal ordering or breeding requirements can be done from anywhere, any time. This facilitates easy communication between different areas of the lab, such as scientists who require a specific number of animals of a certain genotype and the vivarium managers in charge of ordering or breeding these animals.
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Using the internal messaging system, communication happens in real time with a central data repository, no more searching through spreadsheets and email chains!
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Get More out of your Study Data

Frequently, several different studies must be conducted to clearly assess the role of a specific gene in a disease model. Instead of struggling to cross-reference data across multiple spreadsheets or notebooks, use Climb to aggregate data from multiple studies into a single facet.
Climb study management
This data can be filtered, sorted, and exported for analysis in other programs. With data lock features, Climb acts as a secure repository and source of truth should errors in data handling occur.
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Efficient Sample Management

Samples collected during your in vivo experiments are associated with each animal and study in Climb. Easily track sample location and record metadata to circumvent the painful process of digging through freezers and losing valuable sample-associated information vital to data collection and interpretation.
climb sample management capabilities
Climb captures and harmonizes data for every step of your genetic research, including colony management, data collection, and sample tracking.

Empower your scientists, research associates, and vivarium staff to work collaboratively, efficiently, and quickly in Climb’s cloud platform.

Taken together, Climb 2.0 makes will help you get more therapeutics to market faster!

Want to learn more about Climb 2.0?  Take the video tour or request a demo!

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